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hdac3 specific inhibitor rgfp966  (MedChemExpress)


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    MedChemExpress hdac3 specific inhibitor rgfp966
    (A) 3-HB; (B) <t>RGFP966.</t> * p < 0.05, ** p < 0.01, *** p < 0.001.
    Hdac3 Specific Inhibitor Rgfp966, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 69 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hdac3+specific+inhibitor+rgfp966/RGFP966/pmc12913541-53-0-3
    Average 95 stars, based on 69 article reviews
    hdac3 specific inhibitor rgfp966 - by Bioz Stars, 2026-10
    95/100 stars

    Images

    1) Product Images from "Investigating the causal relationship of lipid metabolism in polycystic ovary syndrome: a Mendelian randomization study on the regulatory role of 3-Hydroxybutyrate in gene expression"

    Article Title: Investigating the causal relationship of lipid metabolism in polycystic ovary syndrome: a Mendelian randomization study on the regulatory role of 3-Hydroxybutyrate in gene expression

    Journal: Frontiers in Medicine

    doi: 10.3389/fmed.2026.1747593

    (A) 3-HB; (B) RGFP966. * p < 0.05, ** p < 0.01, *** p < 0.001.
    Figure Legend Snippet: (A) 3-HB; (B) RGFP966. * p < 0.05, ** p < 0.01, *** p < 0.001.

    Techniques Used:

    Related Articles

    other:

    Article Title: Investigating the causal relationship of lipid metabolism in polycystic ovary syndrome: a Mendelian randomization study on the regulatory role of 3-Hydroxybutyrate in gene expression
    Article Snippet: HDAC3-specific inhibitor RGFP966 (MCE, Catalog No. HY-13909), 3-Hydroxybutyrate (MCE, Catalog No. HY-113378).



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    hdac3 specific inhibitor rgfp966  (MedChemExpress)
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    MedChemExpress hdac3 specific inhibitor rgfp966
    (A) 3-HB; (B) <t>RGFP966.</t> * p < 0.05, ** p < 0.01, *** p < 0.001.
    Hdac3 Specific Inhibitor Rgfp966, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hdac3+specific+inhibitor+rgfp966/RGFP966/pmc12913541-53-0-3
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    hdac3 specific inhibitor rgfp966  (Selleck Chemicals)
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    KAE alleviates myocardial injury and oxidative stress by inhibiting <t>HDAC3.</t> (A and B) The effect of KAE on the mRNA and protein expression of HDAC3 in the myocardial tissue of rats was determined. Data are presented as mean ± SEM (n = 6). ** P < 0.01 vs. vehicle group, # P < 0.05, ## P < 0.01 vs. ISO-treated group. (C and D) The effect of KAE on HDAC3 expression in CoCl 2 -stimulated H9c2 cell. H9c2 cells were pretreated with <t>RGFP966,</t> and then treated with KAE followed by incubation with CoCl 2 for 24 h. (E and F) Cell viability and LDH concentration in culture supernatants were measured. (G and H) The levels MDA and SOD in cell homogenates were determined. (I and J) ROS production was measured using the DCFH-DA. (K and L) The effect of HDAC3 overexpression on ROS production was detected using the DHE. Data are presented as mean ± SEM (n = 3). ** P < 0.01 vs. vehicle group, # P < 0.05, ## P < 0.01 vs. CoCl 2 -treated group, $ P < 0.05, $ $ P < 0.01 vs . KAE and CoCl 2 co-treatment group.
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    hdac3-specific inhibitor rgfp966 s82976  (Shanghai Yuanye Biochemicals)
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    KAE alleviates myocardial injury and oxidative stress by inhibiting <t>HDAC3.</t> (A and B) The effect of KAE on the mRNA and protein expression of HDAC3 in the myocardial tissue of rats was determined. Data are presented as mean ± SEM (n = 6). ** P < 0.01 vs. vehicle group, # P < 0.05, ## P < 0.01 vs. ISO-treated group. (C and D) The effect of KAE on HDAC3 expression in CoCl 2 -stimulated H9c2 cell. H9c2 cells were pretreated with <t>RGFP966,</t> and then treated with KAE followed by incubation with CoCl 2 for 24 h. (E and F) Cell viability and LDH concentration in culture supernatants were measured. (G and H) The levels MDA and SOD in cell homogenates were determined. (I and J) ROS production was measured using the DCFH-DA. (K and L) The effect of HDAC3 overexpression on ROS production was detected using the DHE. Data are presented as mean ± SEM (n = 3). ** P < 0.01 vs. vehicle group, # P < 0.05, ## P < 0.01 vs. CoCl 2 -treated group, $ P < 0.05, $ $ P < 0.01 vs . KAE and CoCl 2 co-treatment group.
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    hdac3-specific inhibitor rgfp966 cayman chemical  (Cayman Chemical)
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    KAE alleviates myocardial injury and oxidative stress by inhibiting <t>HDAC3.</t> (A and B) The effect of KAE on the mRNA and protein expression of HDAC3 in the myocardial tissue of rats was determined. Data are presented as mean ± SEM (n = 6). ** P < 0.01 vs. vehicle group, # P < 0.05, ## P < 0.01 vs. ISO-treated group. (C and D) The effect of KAE on HDAC3 expression in CoCl 2 -stimulated H9c2 cell. H9c2 cells were pretreated with <t>RGFP966,</t> and then treated with KAE followed by incubation with CoCl 2 for 24 h. (E and F) Cell viability and LDH concentration in culture supernatants were measured. (G and H) The levels MDA and SOD in cell homogenates were determined. (I and J) ROS production was measured using the DCFH-DA. (K and L) The effect of HDAC3 overexpression on ROS production was detected using the DHE. Data are presented as mean ± SEM (n = 3). ** P < 0.01 vs. vehicle group, # P < 0.05, ## P < 0.01 vs. CoCl 2 -treated group, $ P < 0.05, $ $ P < 0.01 vs . KAE and CoCl 2 co-treatment group.
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    hdac3-specific inhibitor rgfp966  (Cayman Chemical)
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    KAE alleviates myocardial injury and oxidative stress by inhibiting <t>HDAC3.</t> (A and B) The effect of KAE on the mRNA and protein expression of HDAC3 in the myocardial tissue of rats was determined. Data are presented as mean ± SEM (n = 6). ** P < 0.01 vs. vehicle group, # P < 0.05, ## P < 0.01 vs. ISO-treated group. (C and D) The effect of KAE on HDAC3 expression in CoCl 2 -stimulated H9c2 cell. H9c2 cells were pretreated with <t>RGFP966,</t> and then treated with KAE followed by incubation with CoCl 2 for 24 h. (E and F) Cell viability and LDH concentration in culture supernatants were measured. (G and H) The levels MDA and SOD in cell homogenates were determined. (I and J) ROS production was measured using the DCFH-DA. (K and L) The effect of HDAC3 overexpression on ROS production was detected using the DHE. Data are presented as mean ± SEM (n = 3). ** P < 0.01 vs. vehicle group, # P < 0.05, ## P < 0.01 vs. CoCl 2 -treated group, $ P < 0.05, $ $ P < 0.01 vs . KAE and CoCl 2 co-treatment group.
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    Image Search Results


    (A) 3-HB; (B) RGFP966. * p < 0.05, ** p < 0.01, *** p < 0.001.

    Journal: Frontiers in Medicine

    Article Title: Investigating the causal relationship of lipid metabolism in polycystic ovary syndrome: a Mendelian randomization study on the regulatory role of 3-Hydroxybutyrate in gene expression

    doi: 10.3389/fmed.2026.1747593

    Figure Lengend Snippet: (A) 3-HB; (B) RGFP966. * p < 0.05, ** p < 0.01, *** p < 0.001.

    Article Snippet: HDAC3-specific inhibitor RGFP966 (MCE, Catalog No. HY-13909), 3-Hydroxybutyrate (MCE, Catalog No. HY-113378).

    Techniques:

    KAE alleviates myocardial injury and oxidative stress by inhibiting HDAC3. (A and B) The effect of KAE on the mRNA and protein expression of HDAC3 in the myocardial tissue of rats was determined. Data are presented as mean ± SEM (n = 6). ** P < 0.01 vs. vehicle group, # P < 0.05, ## P < 0.01 vs. ISO-treated group. (C and D) The effect of KAE on HDAC3 expression in CoCl 2 -stimulated H9c2 cell. H9c2 cells were pretreated with RGFP966, and then treated with KAE followed by incubation with CoCl 2 for 24 h. (E and F) Cell viability and LDH concentration in culture supernatants were measured. (G and H) The levels MDA and SOD in cell homogenates were determined. (I and J) ROS production was measured using the DCFH-DA. (K and L) The effect of HDAC3 overexpression on ROS production was detected using the DHE. Data are presented as mean ± SEM (n = 3). ** P < 0.01 vs. vehicle group, # P < 0.05, ## P < 0.01 vs. CoCl 2 -treated group, $ P < 0.05, $ $ P < 0.01 vs . KAE and CoCl 2 co-treatment group.

    Journal: Journal of Advanced Research

    Article Title: Kaempferol alleviates myocardial ischemia injury by reducing oxidative stress via the HDAC3-mediated Nrf2 signaling pathway

    doi: 10.1016/j.jare.2024.10.037

    Figure Lengend Snippet: KAE alleviates myocardial injury and oxidative stress by inhibiting HDAC3. (A and B) The effect of KAE on the mRNA and protein expression of HDAC3 in the myocardial tissue of rats was determined. Data are presented as mean ± SEM (n = 6). ** P < 0.01 vs. vehicle group, # P < 0.05, ## P < 0.01 vs. ISO-treated group. (C and D) The effect of KAE on HDAC3 expression in CoCl 2 -stimulated H9c2 cell. H9c2 cells were pretreated with RGFP966, and then treated with KAE followed by incubation with CoCl 2 for 24 h. (E and F) Cell viability and LDH concentration in culture supernatants were measured. (G and H) The levels MDA and SOD in cell homogenates were determined. (I and J) ROS production was measured using the DCFH-DA. (K and L) The effect of HDAC3 overexpression on ROS production was detected using the DHE. Data are presented as mean ± SEM (n = 3). ** P < 0.01 vs. vehicle group, # P < 0.05, ## P < 0.01 vs. CoCl 2 -treated group, $ P < 0.05, $ $ P < 0.01 vs . KAE and CoCl 2 co-treatment group.

    Article Snippet: The HDAC3 specific inhibitor RGFP966 and Nrf2 inhibitor ML385 were from Selleck (Houston, USA).

    Techniques: Expressing, Incubation, Concentration Assay, Over Expression

    KAE alleviates myocardial ischemia injury by reducing oxidative stress via the HDAC3-mediated Nrf2 signaling pathway. (A-C) The Nrf2 expression in myocardial tissue were measured by immunofluorescence and qRT-PCR, respectively. Data are presented as mean ± SEM (n = 6). ** P < 0.01 vs. vehicle group, # P < 0.05, ## P < 0.01 vs. ISO-treated group. (D-F) The effect of KAE on Nrf2 expression in CoCl 2 -stimulated H9c2 cell was determined. (G and H) The effect of Nrf2 inhibition on ROS generation in CoCl 2 -induced H9c2 cells. (I-K) The effect of RGFP966 on Nrf2 expression in KAE-treated H9c2 cells. (L-N) The effect of HDAC3 overexpression on Nrf2 expression in KAE-treated H9c2 cells. (O) Immunoprecipitation of protein from H9c2 cells treated with RGFP966. (P) The effect of HDAC3 overexpression on the acetylation level of Nrf2 in KAE-treated H9c2 cells. Data are presented as mean ± SEM (n = 3). * P < 0.05, ** P < 0.01 vs. vehicle group, # P < 0.05, ## P < 0.01 vs. CoCl 2 -treated group, $ P < 0.05, $ $ P < 0.01 vs. KAE and CoCl 2 co-treatment group.

    Journal: Journal of Advanced Research

    Article Title: Kaempferol alleviates myocardial ischemia injury by reducing oxidative stress via the HDAC3-mediated Nrf2 signaling pathway

    doi: 10.1016/j.jare.2024.10.037

    Figure Lengend Snippet: KAE alleviates myocardial ischemia injury by reducing oxidative stress via the HDAC3-mediated Nrf2 signaling pathway. (A-C) The Nrf2 expression in myocardial tissue were measured by immunofluorescence and qRT-PCR, respectively. Data are presented as mean ± SEM (n = 6). ** P < 0.01 vs. vehicle group, # P < 0.05, ## P < 0.01 vs. ISO-treated group. (D-F) The effect of KAE on Nrf2 expression in CoCl 2 -stimulated H9c2 cell was determined. (G and H) The effect of Nrf2 inhibition on ROS generation in CoCl 2 -induced H9c2 cells. (I-K) The effect of RGFP966 on Nrf2 expression in KAE-treated H9c2 cells. (L-N) The effect of HDAC3 overexpression on Nrf2 expression in KAE-treated H9c2 cells. (O) Immunoprecipitation of protein from H9c2 cells treated with RGFP966. (P) The effect of HDAC3 overexpression on the acetylation level of Nrf2 in KAE-treated H9c2 cells. Data are presented as mean ± SEM (n = 3). * P < 0.05, ** P < 0.01 vs. vehicle group, # P < 0.05, ## P < 0.01 vs. CoCl 2 -treated group, $ P < 0.05, $ $ P < 0.01 vs. KAE and CoCl 2 co-treatment group.

    Article Snippet: The HDAC3 specific inhibitor RGFP966 and Nrf2 inhibitor ML385 were from Selleck (Houston, USA).

    Techniques: Expressing, Immunofluorescence, Quantitative RT-PCR, Inhibition, Over Expression, Immunoprecipitation